Protein Expression & Analysis

Active Cytokines

High bioactivity recombinant cytokines guaranteed for exceptional purity and consistency across your cell signaling research.

Cytokines are small, highly potent proteins that play a crucial role in cell signaling. They act as essential messengers between cells, regulating various immune responses, systemic inflammation, and communication among cells of the immune system.

Produced by a wide range of cells—including immune cells (such as macrophages, lymphocytes, and dendritic cells), endothelial cells, and fibroblasts—cytokines regulate and coordinate massive physiological functions.

Cytokines function by binding to specific, high-affinity receptors on target cells. This transmits signals that can lead to rapid changes in gene expression, cell proliferation, differentiation, migration, and apoptosis. They actively regulate the intensity and duration of immune responses, playing foundational roles in both innate and adaptive immunity.

Major cytokine families include Interleukins, Interferons, Tumour Necrosis Factors (TNFs), Chemokines, and Growth Factors. Each family has distinct, specialized functions critical to maintaining normal physiological homeostasis.

1. Why are Active Cytokines so important in research?

In essence, active cytokines are central to many areas of biomedical research. Their study helps unravel the intricate mechanisms governing immune responses and directly aids in the development of novel therapeutic strategies.

1

Understanding Immune Responses & Inflammation

Cytokines play a pivotal role in initiating and regulating inflammation. Studying active cytokines is crucial for understanding autoimmune diseases, allergies, infections, neurodegenerative disorders, and chronic inflammatory conditions.

2

Drug Development & Therapeutics

Many modern biologics are designed to target cytokines or their receptors to modulate immune responses. Researching active cytokines provides insights into potential drug targets for conditions like rheumatoid arthritis, inflammatory bowel disease, and various cancers (via targeted cytokine therapies or antagonists).

3

Diagnostic Biomarkers

Certain cytokines serve as highly accurate biomarkers for specific diseases. Researchers use them to diagnose conditions, monitor disease progression, and quantitatively assess patient responses to treatments.

2. How to Select the Right Active Cytokine

Finding the "perfect" active cytokine for your cell culture or in vitro assay involves considering several critical factors based on your specific therapeutic goals:

• Biological Activity: Confirm that the cytokine is biologically active and exhibits the desired effects. Check the validation data for evidence supporting its functionality in relevant cell-based assays or experimental models.
• Protein Purity: Ensure the cytokine is of high purity. A purity level of ≥95% is required to avoid unwanted off-target effects from purification impurities that could influence cellular responses.
• Endotoxin Levels: In cell culture experiments, endotoxin (LPS) levels must be extremely low to avoid unintended, massive immune activation. Endotoxin levels should ideally be validated strictly below 1.0 EU/μg.
• Host/Source Species: Ensure the recombinant protein was expressed in a system (e.g., E. coli, HEK293, CHO) appropriate for your necessary post-translational modifications (like glycosylation).

3. Browse by Protein Family

At Biorbyt, we present an extensive selection of active recombinant cytokines, guaranteeing exceptional purity, validated bioactivity, and quality consistency throughout each batch.

Interleukins (ILs)

Cat. Code	Protein Name	Cat. Code	Protein Name
orb867311	IL-1 alpha	orb1087555	IL-2
orb257601	IL-6	orb257598	IL-4
orb419321	IL-12 alpha	orb358978	IL-13

Growth Factors

Cat. Code	Protein Name	Cat. Code	Protein Name
orb257923	VEGF165	orb1146986	IGF-I
orb257918	VEGF121	orb257996	TGF-beta 1
orb762429	EGF	orb1496221	VEGF110

Tumour Necrosis Factors (TNFs)

Cat. Code	Protein Name	Cat. Code	Protein Name
orb257883	TNF-alpha	orb359191	TNFSF9
orb705344	TNFSF14	orb594873	CD40 Ligand
orb1149290	TNFSF11	orb1733281	TNF-beta

Chemokines

Cat. Code	Protein Name	Cat. Code	Protein Name
orb594818	CXCL8	orb359066	CCL2
orb359056	CXCL10	orb359071	CCL5
orb1818955	CXCL14	orb1496251	CXCL13

Interferons

Cat. Code	Protein Name	Cat. Code	Protein Name
orb735041	IFN-alpha 1	orb257562	IFN-gamma
orb867302	IFN-alpha / beta R1	orb594801	IFN-lambda 3
orb359211	IFN-alpha 2	orb359216	IFN-omega 1

4. Related Scientific Guides

Hallmarks of Cancer

CD3 Reagents

Stem Cells

VEGF Signalling Pathway

Got a question about our active cytokine catalog? Contact our technical support team.