Custom Polyclonal Antibody Production

 

Polyclonal antibody production involves immunising an animal with a specific antigen, which triggers the animal's immune system to produce a variety of antibodies targeting different epitopes on the antigen. These antibodies are then harvested from the animal's serum or plasma. Since multiple B cells are involved in producing antibodies, the resulting antibody mixture is referred to as "polyclonal." These antibodies recognise various epitopes on the antigen, leading to broad binding specificity.

Biorbyt provides a reliable and diverse range of custom polyclonal antibody production services, offering multiple options for immunogens and host species to accommodate various research requirements.

Advantages of Biorbyt's Polyclonal Antibody Products

• Broad Binding Specificity

  Polyclonal antibodies recognise multiple epitopes on the target antigen, providing broader binding specificity compared to monoclonal antibodies.

• High sensitivity

  Due to their ability to bind to multiple epitopes, polyclonal antibodies often exhibit higher sensitivity in assays, enabling detection of low-abundance targets.

• Availability

  Polyclonal antibodies can be generated relatively quickly and cost-effectively.

• Versatility

  Polyclonal antibodies are useful for detecting various forms and isoforms of target proteins, making them versatile tools for research, diagnostics, and therapeutic applications.

• Natural Immune Response

  Polyclonal antibodies mimic the natural immune response, providing a diverse repertoire of antibodies similar to those produced in vivo.

• Cross-Reactivity

  Polyclonal antibodies may exhibit cross-reactivity with related antigens, allowing for the detection of closely related targets

Service Process

Peptide

Lead Time: 12-15 weeks

Recombinant Protein

Lead Time: 15-17 weeks

Native Protein

Lead Time: 12-15 weeks

Process

1. Antigen preparation
2. The animals are immunised
3. Serum titer is detected
4. Affinity or protein A/G purification
5. WB validation with antigen

Deliverables

• QC report of antigen
• ELISA titer guarantee 1:10000
• WB guarantee for antigen
• 1 ml of preimmune serum. 2 ml of antiserum
• Antibody purity guarantee 90% by SDS-PAGE detection

 

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