Signaling Pathways

Research into signaling pathways studies how cells communicate with each other and respond to changes in their environment. Understanding the molecular mechanisms of signaling pathways can provide insights into the regulation of cell growth and division, differentiation, and death, as well as provide insights into the development of various diseases including cancer, diabetes, and other metabolic disorders.

Featured Signaling Pathways

Neurodegeneration Focus

 

Alzheimer's Pathway

Alzheimer's disease (AD) is a debilitating neurodegenerative disorder characterized by extracellular amyloid-beta plaques and intracellular neurofibrillary tangles composed of hyperphosphorylated tau proteins.

Explore Alzheimer's Pathway >

Cell Death Focus

 

Apoptosis Pathway

Apoptosis is the process of programmed cell death characterized by distinct morphological characteristics and energy-dependent biochemical mechanisms essential for tissue development and homeostasis.

Explore Apoptosis Pathway >

 

GPCR Pathway

G-protein-coupled receptors (GPCRs) are the largest and most diverse group of membrane receptors in eukaryotes, mediating crucial cellular responses to external stimuli.

Explore GPCR Pathway >

 

Hippo Pathway

The major functions of the Hippo pathway have been defined to restrict tissue growth in adults and govern critical organ size control during embryonic development.

Explore Hippo Pathway >

 

JAK/STAT Pathway

The JAK/STAT pathway is an evolutionarily conserved signaling cascade that mediates cellular responses to cytokines, interferons, and essential growth factors.

Explore JAK/STAT Pathway >

 

MAPK Pathway

The MAPK family is a group of serine/threonine kinases that mediate intracellular signaling associated with proliferation, differentiation, cell survival, and apoptosis.

Explore MAPK Pathway >

 

NF-κB Pathway

Transcriptional programs regulated by NF-κB are essential to the development and maintenance of the immune system, inflammation, and cellular survival cascades.

Explore NF-κB Pathway >

 

VEGF Pathway

VEGFs are master regulators of vascular development and of blood and lymphatic vessel function during embryogenesis, tissue remodeling, and tumor angiogenesis.

Explore VEGF Pathway >

 

Wnt Pathway

Wnt proteins are a family of secreted glycolipids involved in the regulation of embryogenesis, stem cell maintenance, and normal tissue architecture.

Explore Wnt Pathway >

 

mTOR Pathway

The mTOR signaling pathway integrates both intracellular and extracellular signals to serve as a central regulator of cell metabolism, growth, proliferation, and survival.

Explore mTOR Pathway >

 

Notch Pathway

The Notch signaling pathway is a conserved cell signaling system present in most animals that governs cell-fate determination, differentiation, and tissue patterning.

Explore Notch Pathway >