Human IFN-alpha / beta R1 Protein

• Catalog Number: orb867302
• Category: Proteins
• Description: Interferon alpha/beta receptor 1 ( IFNAR1) is also known as Cytokine receptor class-II member 1, Cytokine receptor family 2 member 1 (CRF2-1), Type I interferon receptor 1, IFNAR, which belongs to the type II cytokine receptor family. IFNAR1 /IFNAR contains four fibronectin type-III domains. IFNAR1 associates with IFNAR2 to form the type I interferon receptor. IFNAR1 is receptor for interferons alpha and beta. IFNAR1 can transduce IFNB signals without the help of IFNAR2, and not activating the Jak-STAT pathway.
• Reactivity: Human
• Tag: C-10×His
• Form/Appearance: Powder
• Purity: 95%
• Conjugation: Unconjugated
• MW: 49.0 kDa
• Target: IFN-alpha/beta R1
• Source: Human IFN-alpha / beta R1 Protein, His Tag (orb867302) is expressed from human 293 cells (HEK293). It contains AA Lys 28 - Lys 436 (Accession # P17181-1).
• Expression System: HEK293
• Biological Activity: Loaded Human IFNAR1, His Tag on NTA Biosensor, can bind Human IFN-alpha 2b Protein, Fc Tag with an affinity constant of 0.689 μM as determined in BLI assay (ForteBio Octet Red96e) (QC tested).
• Expression Region: Lys 28 - Lys 436
• Endotoxins: 1.0 EU per μg
• NCBI: NP_000620.2
• Storage: -20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
• Buffer/Preservatives: PBS, pH7.4
• Alternative names: IFNAR1,IFNAR,CRF2-1,IFN-R-1,IFNAR-1
• Note: For research use only
• Application notes: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 49.0 kDa. The protein migrates as 65-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Expiration Date: 6 months from date of receipt.

Loaded Human IFNAR1, His Tag (Cat. No. orb867302) on NTA Biosensor, can bind Human IFN-alpha 2b Protein, Fc Tag with an affinity constant of 0.689 μM as determined in BLI assay (ForteBio Octet Red96e) (QC tested).