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CD18 Antibody / ITGB2 / LFA-1
Catalog Number: orb749614
| Catalog Number | orb749614 |
|---|---|
| Category | Antibodies |
| Description | It recognizes a transmembrane glycoprotein of 95kDa, identified as CD18 or integrin -2 (Workshop III). It complexes non-covalently with either L, M, or X integrin (CD11a, b, or c) to form the heterodimers, LFA-1, Mac-1, and p150,95, respectively. LFA-1 is the receptor for three members of the Ig supergene family of proteins, ICAM-1 (CD54), ICAM-2 (CD102), and Mac-1 and p150,95 bind to ICAM-1, fibrinogen, and iC3b. ICAM-3 (CD50). CD18/CD11 heterodimeric molecules are involved with cell/cell and cell/extracellular adhesion in immune and inflammatory responses. This mAb blocks these cellular interactions. |
| Clonality | Monoclonal |
| Species/Host | Mouse |
| Isotype | Mouse IgG2a, kappa |
| Conjugation | Unconjugated |
| Reactivity | Human |
| Immunogen | Stimulated human leukocytes were used as the immunogen for the CD18 antibody. |
| UniProt ID | P05107 |
| Tested applications | FACS, Functional Studies, IF |
| Dilution range | Functional studies (order BSA/sodium azide-free format),Flow cytometry: 1-2ug/million cells,Immunofluorescence: 1-2ug/ml |
| Application notes | Optimal dilution of the CD18 antibody should be determined by the researcher. |
| Antibody Type | Primary Antibody |
| Clone Number | 68-5A5 |
| Formula | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Hazard Information | This CD18 antibody is available for research use only. |
| Note | For research use only |
SDS-PAGE Analysis of Purified, BSA-Free CD18 Antibody (clone 68-5A5). Confirmation of Integrity and Purity of the Antibody.
