The importance of research in the Neuroscience area cannot be overstated. According to the World Health Organisation’s last estimate, more than one billion people are affected with neurological disease globally. Of these, over 50 million suffer with epilepsy and 24 million with Alzheimer’s and other dementias. This number is only set to rise with an aging global population.
Research into this key area is therefore essential, so it is also a core focus for Biorbyt to provide quality reagents to meet researcher’s needs. Offering high quality antibodies, proteins, ELISA kits and small molecules, we supply products across the board to move your vital research forward.
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The progressive structural and functional loss of structures and/or death of neurons. Research is helping decipher the causes of neurodegenerative diseases like ALS (MND), Alzheimer’s, Parkinson’s and Huntingdon’s at a subcellular level.
Immunohistochemical analysis of paraffin-embedded rat hippocampal tissue using Tau antibody - orb11453
Explore related pathways:
This encompasses the development of neurons from undifferentiated progenitor cells into all mature neurons in the CNS. The process is most prolific during embryonic development, but it is now also known that it occurs in the adult brain. This gives plasticity to the circuitry and increasing evidence shows there is a role for adult neurogenesis in specific brain functions.
Neural Stem Cells
Neuroepithelial cells that are the main cell type in the neural plate constitute the major initial class of neural stem cells. They can go through asymmetric and symmetric division and give rise to radial glial cells, which later generate neurons, astrocytes and oligodendrocytes. It is also well established that the adult brain contains a large number of stem cells. Human Embryonic stem cells (hESC) and induced pluripotent stem cells (IPS) have provided a potentially unlimited source of neural stem cells for clinical use.
Immunohistochemical staining of paraffin embedded rat kidney tissue using Nestin antibody (5 ug/ml) - orb11109
Neuronal Growth and Development
Neurons and their precursors undergo prolific differentiation and migration from their original position in the ventricular zone of the neural tube. They need to migrate outwards to reach their final locations. This is known as radial migration. Radial glial guidance is a key contributory factor in this process.
Neurotransmitter receptors are integral membrane proteins that bind chemical mediators known as neurotransmitters. Binding of neurotransmitters forms the basis for neuronal communication through synaptic junctions between adjacent neurons. Neurotransmitter receptors are critical targets in clinical intervention and the loss or misregulation of these pathways often underpins the symptoms of neurological disease.
Immunohistochemical staining of paraffin embedded human heart tissue using S100A1 antibody (primary antibody at 1:200) - orb95982