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WRN inhibitor 8

SKU: orb2564486

Description

WRN inhibitor 8 (Example 224) is a potent small molecule inhibitor of the WRN helicase with an IC50 of 48 nM. It is a valuable chemical tool for cancer research, particularly in studying synthetic lethal approaches for microsatellite unstable (MSI) cancers in both in vitro and in vivo models.

Research Area

Cell Biology, Epigenetics & Chromatin; Pharmacology & Drug Discovery, Molecular Biology

Images & Validation

Key Properties

CAS Number3026502-95-1
MW463.50
FormulaC22H23F2N3O4S
SMILESO(C=1C(C(N[C@H](/C=C/S(C)(=O)=O)C2CC2)=O)=CN=C(C(F)(F)C3CC3)N1)C4=CC=CC=C4
TargetDNA/RNA Synthesis

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Key Properties

No computed properties available.

Protocol Information