MIRA-1

SKU: orb1305761

Description

MIRA-1

Research Area

Cell Biology, Molecular Biology

Key Properties

• CAS Number: 72835-26-8
• MW: 183.16
• Purity: 99.38% (May vary between batches)
• Formula: C₈H₉NO₄
• SMILES: CCC(=O)OCN1C(=O)C=CC1=O
• Target: DNA/RNA Synthesis,p53,MDM-2/p53,Apoptosis
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (10.92 mM);DMSO:20 mg/mL (109.19 mM);Ethanol:20 mg/mL (109.19 mM)

Bioactivity

• Target IC50:
  WRN helicase:20 µM|p53:10μM
• In Vitro:
  MIRA-1 induces p53 transcriptional transactivation of p21, MDM2, and PUMA, and promotes tumor cell death by apoptosis in a mutant p53-dependent manner in vitro with an IC50 of 10μM.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

RNASynthesis, RNA Synthesis, Saos-2, SKOV, WRN helicase, WRN Helicase Inhibitor, H1299, MDM-2/p53, Inhibitor, inhibit, NSC 19630, MIRA 1, MIRA1, MIRA-1, p53 Activator VIII, p53, NSC19630, NSC-19630, DNA Synthesis, DNASynthesis, Anticancer, Apoptosis, 1-[(1-Oxopropoxy)methyl]-1H-pyrrole-2,5-dione, (2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl propionate

Compound Identifiers

PubChem CID

227681