WRN-IN-24

SKU: orb3210100

Description

WRN-IN-24 is an orally active allosteric covalent inhibitor of the Werner syndrome RecQ DNA helicase (WRN), with an IC50 of 201 nM. It binds to a novel allosteric cavity, forming an additional hydrogen bond with K894, thereby functionally inhibiting WRN activity. WRN-IN-24 suppresses the proliferation of colorectal cancer cells and demonstrates dose-dependent antitumor activity in xenograft mouse models. This compound is applicable in research on cancers with high microsatellite instability, including colorectal cancer.

Key Properties

• CAS Number: 3113010-46-8
• MW: 603.63
• Formula: C₂₄H₂₈F₃N₅O₆S₂
• SMILES: N(C=1C(C(N[C@H](/C=C(/S(C)(=O)=O)\F)[C@H]2CC2)=O)=C(OC3=CC=CC=C3)N=C(C(C)(F)F)N1)C4CN(S(C)(=O)=O)C4
• Target: DNA/RNA Synthesis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

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Gene Symbol

DNA/RNA Synthesis