Werner syndrome RecQ helicase-IN-4

SKU: orb1745123

Description

Werner syndrome RecQ helicase-IN-4 is a potent and selective small molecule inhibitor of the WRN helicase. It demonstrates antiproliferative activity in colorectal and gastric cancer cell lines and is a valuable tool for investigating DNA damage response and synthetic lethality in cancer research models.

Research Area

Cell Biology, Molecular Biology

Key Properties

• CAS Number: 2869954-53-8
• MW: 666.65
• Purity: 98.27% (May vary between batches)
• Formula: C₃₂H₃₃F₃N₈O₅
• SMILES: O=C(C1=NC=CC=C1O)N2CCN(C=3C(=O)N4N=C(N=C4N(C3CC)CC(=O)NC5=CC=C(C=C5C)C(F)(F)F)C6=CCOCC6)CC2
• Target: DNA/RNA Synthesis
• Solubility: DMSO:80 mg/mL (120 mM)

Bioactivity

• Target IC50:
  WRN:0.06 µM
• In Vivo:
  Werner syndrome RecQ helicase-IN-4 (240 mg/kg, 18 days, orally) showed anticancer activity in SW48 xenografted mice.
• In Vitro:
  Werner syndrome RecQ helicase-IN-4 is an inhibitor of RecQ DNA helicase (WRN) with an IC50 value of 0.06 µM.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

166140592