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    Ubiquitin Antibody

    Ubiquitin Antibody

    Catalog Number: orb606656

    DispatchUsually dispatched within 5-10 working days
    $ 764.00
    Catalog Numberorb606656
    CategoryAntibodies
    DescriptionUbiquitin is a highly conserved and plays an essential role in the ubiquitin-proteasome pathway. In ubiquitination process, it is first activated by forming a thiol-ester complex with the activation component E1, which is then transferred to ubiquitin-carrier protein E2, followed by to ubiquitin ligase E3 for final delivery to epsilon-NH2 of the target protein lysine residue. IkB, p53, cdc25A, Bcl-2 etc. are shown as targets of ubiquitin-proteasome process as part of regulation of cell cycle progression, differentiation, cell stress response, and apoptosis. Moreover, ubiquitin have been reported to bind covalently with pathological inclusions which are resistant to degradation e.g. neurofibrillary tangles/paired helical filaments in Alzheimer's disease, Lewy bodies seen in Parkinson's disease, and Pick bodies found in Pick's disease etc.
    Species/HostMouse
    ClonalityMonoclonal
    Clone NumberUBB/1748
    Tested applicationsFACS, IF, IHC-P, WB
    ReactivityHuman
    IsotypeMouse IgG2c, kappa
    ImmunogenA portion of amino acids 1-119 from the human protein was used as the immunogen for the Ubiquitin antibody.
    Dilution rangeFlow cytometry: 1-2ug/million cells,Western blot: 1-2ug/ml,Immunofluorescence: 1-2ug/ml,Immunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT
    PurityProtein G affinity chromatography
    ConjugationUnconjugated
    Formula0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
    Hazard InformationThis Ubiquitin antibody is available for research use only.
    UniProt IDP62988, P62987, P0CG47, P0CG48, P62979
    StorageStore the Ubiquitin antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
    Buffer/Preservatives0.2 mg/ml in 1X PBS with 0.1 mg/ml rAlbumin (US sourced) and 0.05% sodium azide
    NoteFor research use only
    Application notesOptimal dilution of the Ubiquitin antibody should be determined by the researcher.
    Expiration Date12 months from date of receipt.
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