Phosphatase Antibody

SKU: orb3031954

Description

AMG-529 is a humanized monoclonal antibody targeting the asialoglycoprotein receptor 1 (ASGR1). Primarily expressed on hepatocytes, ASGR1 mediates the endocytosis and degradation of circulating asialoglycoproteins. AMG-529 functions by specifically binding to ASGR1 and blocking ligand interactions, thereby inhibiting receptor function. Clinical studies demonstrate that ASGR1 inhibition leads to a dose-dependent elevation in serum alkaline phosphatase (ALP) levels, which serves as a circulating biomarker for suppressed ASGR1 activity. This antibody is utilized in research concerning lipid metabolism regulation and cardiovascular protection mechanisms.

Research Area

Metabolism Research, Signal Transduction

Key Properties

• Antibody Type: Inhibitor Antibody
• Clonality: Monoclonal
• Target: Phosphatase
• Conjugation: Unconjugated

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Phosphatase