HLA-ABC Antibody (MHC I)

• Catalog Number: orb1823223
• Category: Antibodies
• Description: Major Histocompatibility Complex (MHC) is a genetic region on chromosomes composed of tightly linked highly polymorphic gene loci that encode cell surface specific proteins, depending on the structure and function of genes and coding products. We divide MHC into class I (telomeric), class II (centromeric) and class III gene regions. Endogenous antigen presentation is presented by the major histocompatibility complex I (MHC I ) pathway. Intracytoplasmic proteins are decomposed into peptides during protease degradation, which in turn are delivered by HSP41 and HSP90 proteins to TAP on the membrane. MHC I is widely distributed on the surface of almost all nucleated cells, including spleen, lymph nodes and thymus lymphocytes in normal tissues. It is also expressed in skin, lung, kidney, liver and heart tissues. It is also widely expressed in tumor tissues. MHC molecular typing is related to the matching of organ transplantation and bone marrow transplantation, as well as a variety of autoimmune diseases.
• Species/Host: Rabbit
• Clonality: Recombinant
• Clone Number: MHC-I/8147R
• Tested applications: IHC-P
• Reactivity: Human
• Isotype: Rabbit IgG, kappa
• Immunogen: A recombinant partial protein sequence (within amino acids 100-300) from the human protein was used as the immunogen for the HLA-ABC antibody.
• Dilution range: Immunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT
• Conjugation: Unconjugated
• Formula: 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
• Hazard Information: This HLA-ABC antibody is available for research use only.
• UniProt ID: P30443, P30499, P01889
• Storage: Aliquot the HLA-ABC antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.