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HLA-ABC Antibody (MHC I)

Catalog Number: orb1823210

DispatchUsually dispatched within 5-10 working days
$ 780.00
Catalog Numberorb1823210
CategoryAntibodies
DescriptionMajor Histocompatibility Complex (MHC) is a genetic region on chromosomes composed of tightly linked highly polymorphic gene loci that encode cell surface specific proteins, depending on the structure and function of genes and coding products. We divide MHC into class I (telomeric), class II (centromeric) and class III gene regions. Endogenous antigen presentation is presented by the major histocompatibility complex I (MHC I ) pathway. Intracytoplasmic proteins are decomposed into peptides during protease degradation, which in turn are delivered by HSP41 and HSP90 proteins to TAP on the membrane. MHC I is widely distributed on the surface of almost all nucleated cells, including spleen, lymph nodes and thymus lymphocytes in normal tissues. It is also expressed in skin, lung, kidney, liver and heart tissues. It is also widely expressed in tumor tissues. MHC molecular typing is related to the matching of organ transplantation and bone marrow transplantation, as well as a variety of autoimmune diseases.
ClonalityRecombinant
Species/HostRabbit
IsotypeRabbit IgG, kappa
ConjugationUnconjugated
ReactivityHuman
ImmunogenA recombinant partial protein sequence (within amino acids 100-300) from the human protein was used as the immunogen for the HLA-ABC antibody.
UniProt IDP30499, P30443, P01889
Tested applicationsIHC-P
Dilution rangeImmunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT
Antibody TypePrimary Antibody
Clone NumberMHC-I/8366R
Formula1 mg/ml in 1X PBS; BSA free, sodium azide free
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Hazard InformationThis HLA-ABC antibody is available for research use only.
NoteFor research use only
HLA-ABC Antibody (MHC I)

IHC staining of FFPE human tonsil tissue with HLA-ABC antibody (clone MHC-I/8366R). HIER: boil tissue sections in pH9 10 mM Tris with 1 mM EDTA for 20 min and allow to cool before testing.

HLA-ABC Antibody (MHC I)

SDS-PAGE analysis of purified, BSA-free HLA-ABC antibody (clone MHC-I/8366R) as confirmation of integrity and purity.

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