GSK-3β inhibitor 3

SKU: orb1694517

Description

GSK-3β inhibitor 3

Research Area

Cell Biology, Pharmacology & Drug Discovery, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 1448990-73-5
• MW: 327.37
• Purity: 97.53% (May vary between batches)
• Formula: C₁₈H₁₄FNO₂S
• SMILES: Fc1ccc(cc1)C1CC(=O)N(C(=O)C=C)c2ccccc2S1
• Target: GSK-3,Apoptosis
• Solubility: DMSO:225 mg/mL (687.3 mM)

Bioactivity

• Target IC50:
  GSK-3β:6.6 μM (IC50)
• In Vivo:
  GSK-3β inhibitor 3 (compound 4-3) (15 mg/kg; a single i.p.; Balb/c female nude mice) demonstrates a T1/2 of 14.2 hours, an AUClast of 3503.42 ng/mL•h, and a Cmax of 515 ng/mL in mice. Additionally, GSK-3β inhibitor 3 (15 mg/kg/d; i.p. for 2 weeks; Balb/c female nude mice) inhibits tumor growth by 75.97% compared to the vehicle control.
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• In Vitro:
  GSK-3β inhibitor 3 (compound 4-3) (6.25-100 μM; 24-48 h) dose-dependently inhibits cell viability, with IC50s of 19.56 μM and 26.42 μM in NB4 and NB4-R1 cells at 24 h, respectively. It (12.5-100 μM; 24 h) also significantly increases apoptosis in a dose-dependent manner in NB4 and NB4-R1 cells. Additionally, GSK-3β inhibitor 3 (100 μM) inhibits GSK-3α activity by 87.3%.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

GSK3β inhibitor 3, GSK-3β inhibitor 3, GSK-3β, GSK-3beta inhibitor 3, GSK-3b inhibitor 3, GSK3, GSK 3β inhibitor 3, Apoptosis

Compound Identifiers

PubChem CID

155925848