Laduviglusib trihydrochloride

SKU: orb1146475

Description

Laduviglusib (CHIR-99021) trihydrochloride is a well-characterized small molecule inhibitor that specifically targets glycogen synthase kinase-3 alpha and beta (GSK-3α/β). It exhibits potent inhibitory activity with IC50 values of 10 nM for GSK-3α and 6.7 nM for GSK-3β. Importantly, it demonstrates high selectivity, being over 500-fold more selective for GSK-3 compared to other kinases such as CDC2 and ERK2, as well as a broad range of other protein kinases.

Key Properties

• CAS Number: 1782235-14-6
• MW: 574.7207
• Purity: >98%
• Formula: C₂₂H₂₁CL₅N₈
• SMILES: ClC1C([H])=C(C([H])=C([H])C=1C1C(=C([H])N=C(N=1)N([H])C([H])([H])C([H])([H])N([H])C1C([H])=C([H])C(C#N)=C([H])N=1)C1=NC([H])=C(C([H])([H])[H])N1[H])Cl.Cl[H].Cl[H].Cl[H]

Storage & Handling

• Disclaimer: For research use only