Isoangustone A

SKU: orb1682376

Description

Isoangustone A is a cell-permeable natural product that acts as an ATP-competitive inhibitor of PI3K, MKK4, and MKK7. It suppresses G1/S phase progression and Akt/GSK-3β/JNK signaling, demonstrating anti-proliferative effects in human melanoma cells in vitro and reducing tumor growth in mouse xenograft models in vivo.

Research Area

Cell Biology, Immunology & Inflammation, Protein Biochemistry, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 129280-34-8
• MW: 422.47
• Purity: 98.89% (May vary between batches)
• Formula: C₂₅H₂₆O₆
• SMILES: O=C1C(=COC2=CC(O)=C(C(O)=C12)CC=C(C)C)C=3C=C(O)C(O)=C(C3)CC=C(C)C
• Target: JNK,MAPK,Apoptosis,PI3K,Autophagy

Bioactivity

• In Vivo:
  Method: A SK-MEL-28 xenograft tumor model was established using male Balb/c nude (nu/nu) mice. Mice were administered Isoangustone A via daily intraperitoneal injection at doses of 2 or 10 mg/kg for 35 consecutive days to evaluate its antitumor effects. Result: Isoangustone A significantly reduced tumor weight compared to the control group. It also markedly decreased the expression of proliferating cell nuclear antigen (PCNA) and reduced the phosphorylation levels of Akt.
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• In Vitro:
  Method: A cell proliferation assay was performed using the SK-MEL-28 cell line. Cells were treated with Isoangustone A at concentrations of 10 μM and 20 μM for 48 and 72 hours to evaluate its effect on cell proliferation. Result: Isoangustone A significantly inhibited the proliferation of SK-MEL-28 cells in a dose- and time-dependent manner.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NFκB, NF-κB, NFkB, NF-kB, MMP, Isoangustone A, JNK, GSK3, GSK-3, Akt, CDK, TGF-β/Smad, ROS, PI3K

Compound Identifiers

PubChem CID

21591148