YAP-TEAD-IN-1

SKU: orb1983778

Description

YAP-TEAD-IN-1 is a potent, cell-permeable inhibitor that disrupts the YAP-TEAD protein-protein interaction with an IC50 of 25 nM. It binds TEAD1 with high affinity (Kd: 15 nM) and is a valuable tool for probing Hippo pathway signaling in cancer research, applicable in both cellular and biochemical assays.

Research Area

Cancer Biology, Stem Cell & Developmental Biology

Key Properties

• Target: Others,YAP
• CAS Number: 1659305-78-8
• MW: 2019.89
• Formula: C₉₃H₁₄₄ClN₂₃O₂₁S₂
• SMILES: [H][C@@]12CCCN1C(=O)[C@H](CCCC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSSC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC2=O)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(N)=O)NC(=O)[C@H](Cc1cccc(Cl)c1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(C)=O)C(C)C

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

118714486