YAP-TEAD-IN-1 TFA

SKU: orb1679209

Description

YAP-TEAD-IN-1 TFA is a potent, cell-permeable inhibitor of the YAP-TEAD protein-protein interaction, with an IC50 of 25 nM. It binds TEAD1 with high affinity (Kd: 15 nM) and is a valuable chemical probe for studying Hippo pathway signaling in cancer research and in vitro mechanistic studies.

Research Area

Cancer Biology; Immunology & Inflammation, Stem Cell & Developmental Biology

Key Properties

• Target: YAP,Others
• CAS Number: 1659305-79-9
• Formula: C₉₃H₁₄₄ClN₂₃O₂₁S₂.xC₂HF₃O₂
• SMILES: C(C(O)=O)(F)(F)F.C(=O)([C@H]1N(C([C@@H](NC(=O)[C@H]2NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@]4(N(C(=O)[C@H](CCCC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC([C@@H](NC(=O)[C@H]5N(C([C@@H](NC(C)=O)C(C)C)=O)CCC5)CC6=CC(Cl)=CC=C6)=O)CCSSC2)CCC4)[H])CCCCN)=O)CCC1)N7[C@H](C(N[C@@H](CCC(O)=O)C(N)=O)=O)CCC7

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

146012784