Tetracycline hydrochloride

SKU: orb1310176

Description

Tetracycline hydrochloride is a semisynthetic, broad-spectrum antibiotic that inhibits bacterial protein synthesis by preventing tRNA binding to the ribosome. It is widely used in vitro for bacterial selection and in vivo for bone labeling in osteology research due to its specific fluorescence at mineralization fronts.

Research Area

Infectious Disease & Virology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 64-75-5
• MW: 480.90
• Purity: 99.72% (May vary between batches)
• Formula: C₂₂H₂₄N₂O₈·HCl
• SMILES: C[C@@]1([C@H]2C[C@H]3[C@@H](C(=C(C(=O)[C@]3(C(=C2C(=O)c2c1cccc2O)O)O)C(=O)N)O)N(C)C)O.Cl
• Target: ribosome,Antibacterial,Antibiotic
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (8.32 mM);DMSO:126 mg/mL (262.01 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble);H2O:88 mg/mL (182.99 mM)

Bioactivity

• In Vivo:
  Tetracyclines are utilized for managing infections in various livestock, including poultry, cattle, sheep, and swine, and in aquaculture species such as salmon, catfish, and lobsters. In specific scenarios, such as treating large populations of commercially farmed poultry, these antibiotics may be administered directly through feed, water, or aerosols. Additionally, tetracyclines may serve to promote or enhance growth.
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• In Vitro:
  Tetracyclines are versatile broad-spectrum antibiotics effective against a vast array of organisms, including gram-positive and gram-negative bacteria, as well as atypical pathogens like chlamydiae, mycoplasmas, rickettsiae, and protozoan parasites. Their mechanism of action involves blocking bacterial protein synthesis by hindering the binding of aminoacyl-tRNA to the bacterial ribosome. Specifically, in gram-negative enteric bacteria, tetracyclines enter through OmpF and OmpC porin channels as positively charged coordination complexes, likely involving magnesium ().
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Tetracycline HCl, NCI-c55561

Compound Identifiers

PubChem CID

54704426