Sarecycline hydrochloride

SKU: orb1705083

Description

Sarecycline HCl is a narrow-spectrum tetracycline-class antibiotic with demonstrated antimicrobial and anti-inflammatory properties. It is used in research for inflammatory acne studies and has shown in vitro activity against pathogens like Acinetobacter and Candida tropicalis.

Research Area

Cell Biology, Infectious Disease & Virology, Molecular Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1035979-44-2
• MW: 523.96
• Purity: 99.23% (May vary between batches)
• Formula: C₂₄H₃₀ClN₃O₈
• SMILES: O[C@]12[C@]([C@H](N(C)C)C(O)=C(C(N)=O)C1=O)(C[C@]3(C(=C2O)C(=O)C=4C(C3)=C(CN(OC)C)C=CC4O)[H])[H].Cl
• Target: Antibacterial
• Solubility: H2O:5.26 mg/mL (10.04 mM);DMSO:80 mg/mL (152.68 mM)

Bioactivity

• In Vivo:
  METHODS: To determine the in vivo efficacy of Sarecycline hydrochloride against Staphylococcus aureus RN450-1 and Escherichia coli PBS1478, a murine model of systemic (intraperitoneal) infection was utilized. RESULTS: Sarecycline hydrochloride effectively treated systemic infections caused by Staphylococcus aureus, with a protective dose at 50% (PD50) value of 0.25 mg/kg.
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• In Vitro:
  METHODS: To evaluate the antibacterial activity of Sarecycline hydrochloride and its comparator against Cutibacterium acnes, Sarecycline hydrochloride was applied to 55 clinical isolates of Cutibacterium acnes. RESULTS: The MIC values of Sarecycline hydrochloride ranged from 0.5 to 16 μg/ml and it displayed activity against macrolide-resistant strains .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Antibacterial, P 005672, P-005672, P005672, WC-3035, WC 3035, WC3035, Sarecycline HCl

Compound Identifiers

PubChem CID

71296095