Oxytetracycline Hydrochloride

SKU: orb1306365

Description

Oxytetracycline hydrochloride is a broad-spectrum tetracycline antibiotic produced by Streptomyces rimosus. It inhibits bacterial protein synthesis by preventing aminoacyl-tRNA binding to the ribosomal acceptor site. This compound is widely used in in vitro microbiological studies and in vivo animal models of bacterial infection.

Research Area

Immunology & Inflammation, Infectious Disease & Virology, Metabolism Research

Key Properties

• CAS Number: 2058-46-0
• MW: 496.89
• Purity: 99.86% (May vary between batches)
• Formula: C₂₂H₂₅ClN₂O₉
• SMILES: Cl.[H][C@@]12[C@@H](O)[C@@]3([H])C(C(=O)c4c(O)cccc4[C@@]3(C)O)=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@H]2N(C)C
• Target: Antibacterial,Antiviral,HSV,Endogenous Metabolite,Antibiotic
• Solubility: DMSO:60 mg/mL (120.75 mM);H2O:Insoluble;10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (8.05 mM)

Bioactivity

• In Vivo:
  The 10-day effect of oxytetracycline at therapeutic doses (82.8 mg/kg bw to 1 % bw/day) was species-specific. Oxytetracycline increases the enzymatic activity of CYP3A4 in Ictalurus punctatus, increases the protein expression of CYP3A4 in Oreochromis niloticus, and depletes hepatic CYP3A4 in the latter, and also increases the relative liver weight of Morone chrysops x M. saxatilis . Oxytetracycline is limited to 100 μg/kg in muscle and breast milk, 200 μg/kg in eggs, 300 μg/kg in liver, and 600 μg/kg in kidney.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Dalimycin, Dalinmycin, Bacterial, Biosolvomycin, Antiviral, Antibacterial, aminoacil-tRNA, Antibiotic, Inhibitor, Herpes simplex virus, HSV-1, HSV, Human Endogenous Metabolite, Gram-positive, Gram-negative, Endogenous Metabolite, EndogenousMetabolite, inhibit, m-ribosomal, protein, synthesis, tetracycline, Oxytetracycline, Oxytetracycline HCl, Oxytetracycline Hydrochloride, Oxytetracycline, Sodium Salt, Oxytetracycline.HCl

Compound Identifiers

PubChem CID

54680782