Anhydrotetracycline hydrochloride

SKU: orb1705033

Description

Anhydrotetracycline hydrochloride acts as a potent competitive inhibitor of broad-spectrum tetracycline destructase enzymes. This small molecule is a valuable research tool for studying antibiotic resistance mechanisms in both in vitro enzymatic assays and in vivo bacterial models.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 13803-65-1
• MW: 462.88
• Purity: 99.33% (May vary between batches)
• Formula: C₂₂H₂₃ClN₂O₇
• SMILES: Cl.CN(C)[C@H]1[C@@H]2Cc3c(C)c4cccc(O)c4c(O)c3C(=O)[C@]2(O)C(=O)C(C(N)=O)=C1O
• Target: Antibiotic,Antibacterial
• Solubility: 10% DMSO+90% Saline:3.3 mg/mL (7.13 mM);DMSO:125 mg/mL (270.05 mM)

Bioactivity

• Target IC50:
  TetX3:3 μM|TetX:41 μM|Tet50:210 μM
• In Vitro:
  Anhydrotetracycline (hydrochloride), a tetracycline biosynthetic precursor, inhibited Tet50, TetX, TetX-3 degradations of tetracyclines with the IC50s of 210 μM, 41 μM and 3 μM,respectively. Anhydrotetracycline (hydrochloride) inhibited Tet50, TetX, TetX-3 degradations of demeclocycline with the IC50s of 120 μM, 41 μM, 7 μM,respectively. Anhydrotetracycline (hydrochloride) inhibited Tet50, TetX, TetX-3 degradations of chlortetracycline with the IC50s of 210 μM, 75 μM, 26 μM,respectively.

Storage & Handling

• Storage: keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

eukaryotic, enzymes, Inhibitor, inhibit, Antibiotic, Anhydrotetracycline, Anhydrotetracycline hydrochloride, Anhydrotetracycline Hydrochloride, Antibacterial, Bacterial, biosynthetic, demeclocycline, destructase, chlortetracycline, tetracycline, Tet50

Compound Identifiers

PubChem CID

54710409