Terfenadine

SKU: orb1309179

Description

Terfenadine is a prodrug metabolized by CYP3A4 to its active form, fexofenadine, a selective H1-receptor antagonist. This compound is used in pharmacological research to study antihistamine mechanisms, CYP3A4-mediated metabolism, and non-sedative properties in both in vitro and in vivo experimental models.

Research Area

Cell Biology, Immunology & Inflammation, Neuroscience, Pharmacology & Drug Discovery, Protein Biochemistry

Key Properties

• CAS Number: 50679-08-8
• MW: 471.67
• Purity: 98.76% (May vary between batches)
• Formula: C₃₂H₄₁NO₂
• SMILES: CC(C)(C)c1ccc(cc1)C(O)CCCN1CCC(CC1)C(O)(c1ccccc1)c1ccccc1
• Target: AChR,5-HT Receptor,Histamine Receptor,Na+/Ca2+ Exchanger,Potassium Channel,Apoptosis,Caspase
• Solubility: DMSO:47.2 mg/mL (100.07 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.24 mM)

Bioactivity

• Target IC50:
  ERG (human):204 nM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Potassium Channel, PotassiumChannel, Terfenadine, Caspase, Ca2+Exchanger, Ca2+ Exchanger, Apoptosis, 5HT Receptor, (±)-Terfenadine, 5HTReceptor, hERG, Inhibitor, HT, HistamineReceptor, Histamine Receptor, MDL 991, MDL991, MDL-991, inhibit, KcsA, Na+Exchanger, Na+ Exchanger, Na+/Ca2+ Exchanger, mAChR

Compound Identifiers

PubChem CID

5405