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Syk Inhibitor II

SKU: orb1302930

Description

Syk inhibitor II is a cell-permeable, ATP-competitive pyrimidine-carboxamide that selectively and reversibly inhibits Syk kinase with an IC50 of 41 nM. This compound is a valuable research tool for studying Syk-dependent signaling pathways in immunology and oncology, applicable in both cellular and biochemical assays.

Research Area

Cardiovascular Research, Neuroscience, Pharmacology & Drug Discovery, Signal Transduction

Images & Validation

Key Properties

CAS Number726695-51-8
MW340.3
Purity98.52% (May vary between batches)
FormulaC14H15F3N6O
SMILESNCCNc1ncc(C(N)=O)c(Nc2cccc(c2)C(F)(F)F)n1
Target5-HT Receptor,Syk
SolubilityH2O:25 mg/mL (73.46 mM);DMSO:100 mg/mL (293.86 mM)

Bioactivity

Target IC50
PKCε:5.1 μM|Syk:41 nM|ITK:22.6 μM|ZAP70:11.2 μM|5-HT:460 nM|PKCβ2:11 μM|BTK:15.5 μM
In Vitro
In mice,Syk inhibitor II prevents FcεRI-mediated 5-HT release in RBL-2H3 cells in vitro (IC50 = 460 nM) and inhibits passive cutaneous anaphylaxis reactions (ID50 = 13.2 mg/kg, s.c.).

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Spleen tyrosine kinase, Syk Inhibitor II, Syk, pyrimidine-carboxamide, Serotonin Receptor, 5HTReceptor, 5-hydroxytryptamine Receptor, 5-HT Receptor, 5HT Receptor, ATP-competitive, Anti-allergic, antigen, Inhibitor, inhibit

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Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

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Protocol Information

Syk Inhibitor II (orb1302930)

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1 ml x 10 mM (in DMSO)
$ 130.00