Syk Inhibitor II hydrochloride

SKU: orb1685280

Description

Spleen tyrosine kinase (Syk) is a key signaling node for multiple inflammatory stimuli relevant to lupus. Studies in FcgRIIb-deficient models show Syk inhibition reduces inflammatory cytokine production and attenuates sepsis severity, highlighting its potential as a research target for autoimmune and inflammatory disease investigations.

Research Area

Cardiovascular Research, Neuroscience, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 2490508-82-0
• MW: 376.77
• Purity: 99.05% (May vary between batches)
• Formula: C₁₄H₁₆ClF₃N₆O
• SMILES: O=C(C1=CN=C(NCCN)N=C1NC2=CC=CC(C(F)(F)F)=C2)N.[H]Cl
• Target: Others,5-HT Receptor,Syk
• Solubility: DMSO:55 mg/mL (145.98 mM)

Bioactivity

• Target IC50:
  5-HT receptor:460 nM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Syk Inhibitor II Hydrochloride, Syk Inhibitor II hydrochloride

Compound Identifiers

PubChem CID

45263786