Syk Inhibitor II dihydrochloride

• Catalog Number: orb1302895
• Category: Small Molecules
• Description: Syk Inhibitor II (hydrochloride)
• CAS Number: 227449-73-2
• Purity: 99.59%
• MW: 413.22
• SMILES: Cl.Cl.NCCNc1ncc(C(N)=O)c(Nc2cccc(c2)C(F)(F)F)n1
• Formula: C₁₄H₁₇Cl₂F₃N₆O
• Biological Activity: Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that, upon phosphorylation, binds to immunoreceptor tyrosine-based activation motifs of FcRγ chains and mediates downstream signaling related to platelet function and inflammation. Syk inhibitor II is a cell-permeable, pyrimidine-carboxamide compound that selectively and reversibly blocks Syk (IC50 = 41 nM) in an ATP-competitive manner. It is much less potent against PKCε, PKCβII, ZAP-70, Btk, and Itk (IC50s = 5.1, 11, 11.2, 15.5, and 22.6 μM, respectively).
• Note: For research use only
• Expiration Date: 12 months from date of receipt.