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Rg3039

SKU: orb1304311

Description

RG3039 (PF-06687859) is a potent and selective DcpS inhibitor developed for spinal muscular atrophy (SMA) research. It has demonstrated efficacy in preclinical studies, improving survival, motor function, and neuromuscular pathology in SMA mouse models, supporting its investigation as a potential therapeutic strategy.

Research Area

Cell Biology, Molecular Biology

Images & Validation

Key Properties

CAS Number1005504-62-0
MW432.35
Purity99.58% (May vary between batches)
FormulaC21H23Cl2N5O
SMILESNc1nc(N)c2c(OCC3CCN(Cc4c(Cl)cccc4Cl)CC3)cccc2n1
TargetOthers,DNA/RNA Synthesis
SolubilityH2O:< 0.1 mg/mL (insoluble);DMSO:1 mg/mL (2.31 mM)

Bioactivity

Target IC50
DcpS:0.069 nM.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Inhibitor, inhibit, DcpS, RG 3039, Rg3039, Rg-3039, PF06687859, PF-06687859, PF 06687859

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    C21H23Cl2N5O

    1 g, 2 mg, 5 mg, 10 mg, 25 mg, 100 mg, 50 mg, 500 mg
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

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Protocol Information

Rg3039 (orb1304311)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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2 mg
$ 80.00
5 mg
$ 100.00
10 mg
$ 130.00
25 mg
$ 210.00
50 mg
$ 320.00
100 mg
$ 480.00
500 mg
$ 1,030.00
DispatchUsually dispatched within 3-5 working days
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