Rg3039

SKU: orb1304311

Description

RG3039 (PF-06687859) is a potent and selective DcpS inhibitor developed for spinal muscular atrophy (SMA) research. It has demonstrated efficacy in preclinical studies, improving survival, motor function, and neuromuscular pathology in SMA mouse models, supporting its investigation as a potential therapeutic strategy.

Research Area

Cell Biology, Molecular Biology

Key Properties

• CAS Number: 1005504-62-0
• MW: 432.35
• Purity: 98.24% (May vary between batches)
• Formula: C₂₁H₂₃Cl₂N₅O
• SMILES: Nc1nc(N)c2c(OCC3CCN(Cc4c(Cl)cccc4Cl)CC3)cccc2n1
• Target: DNA/RNA Synthesis,Others
• Solubility: H2O:< 0.1 mg/mL (insoluble);DMSO:1 mg/mL (2.31 mM)

Bioactivity

• Target IC50:
  DcpS:0.069 nM.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, DcpS, RG 3039, Rg3039, Rg-3039, PF06687859, PF-06687859, PF 06687859

Compound Identifiers

PubChem CID

53258905