RG3039 hydrochloride

SKU: orb3211268

Description

RG3039 hydrochloride is an orally active DcpS inhibitor capable of crossing the blood-brain barrier, with an IC50 of 4.2 nM for hDcpS. It inhibits the decapping activity of DcpS, maintaining the enzyme in a non-catalytic conformation within the central nervous system and other tissues. RG3039 hydrochloride extends survival and improves functionality in mouse models of spinal muscular atrophy, making it useful for research related to this condition.

Key Properties

• CAS Number: 1466525-84-7
• MW: 505.27
• Formula: C₂₁H₂₅Cl₄N₅O
• SMILES: ClC1=CC=CC(Cl)=C1CN2CCC(CC2)COC3=C4C(N)=NC(N)=NC4=CC=C3.Cl.Cl
• Target: DNA/RNA Synthesis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

DNA/RNA Synthesis