Rg3039

SKU: orb1222934

Description

RG3039, also known as PF-06687859, is a potent DcpS inhibitor. DcpS is a therapeutic target for spinal muscular atrophy. Spinal muscular atrophy (SMA) is caused by deletion or mutation of both copies of the SMN1 gene which produces an essential protein known as SMN. RG3039 improves motor function in SMA mice. RG3039 also showed activity to improve survival, function and motor unit pathologies in two SMA mouse models.

Key Properties

• CAS Number: 1005504-62-0
• MW: 432.35
• Purity: >98% (HPLC)
• Formula: C₂₁H₂₃Cl₂N₅O
• SMILES: C1CN(CCC1COc1cccc2c1c(nc(n2)N)N)Cc1c(cccc1Cl)Cl
• Target: GPR
• Solubility: DMSO : 6 mg/mL 13.88 mM; H2O : < 0.1 mg/mL

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

RG3039 | RG 3039 | PF 06687859 | PF-06687859

Quick Database Links

Gene Symbol

GPR