Cart summary

You have no items in your shopping cart.

JCS-1

SKU: orb2814409

Description

JCS-1 is a potent, nanomolar DcpS PROTAC degrader (DC50 = 87 nM in MOLM-14 cells) that utilizes an RG3039-based warhead to recruit the VHL E3 ligase. This tool compound enables the study of DcpS-dependent mechanisms in acute myeloid leukemia research and related genetic disorders in cellular models.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Images & Validation

Key Properties

MW1174.41
FormulaC62H79N9O12S
TargetPhosphatase,PROTACs

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Documents Download

Datasheet
Product Information
Download

Request a Document

Protocol Information

JCS-1 (orb2814409)

  • Star
  • Star
  • Star
  • Star
  • Star
  • 0.0
Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

Login to Submit a Review

No reviews yet

Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

Step 2: Enter the in vivo formulation

(This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO +
%+
% Tween 80 +
%