REL (C) Antibody, Rabbit Polyclonal

SKU: orb67271

Description

Rabbit polyclonal to REL.Proto-oncogene c-Rel EL) is a member of the NF-kappa-B transcription factor family. NF-kappa-Bis a pleiotropic transcription factor present in almost all cell types and is involved in many biologicalprocessed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis.NF-kappa-B is a homo-or heterodimeric complex formed by the Rel-like domain-containing proteinsRELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind to the kappa-Bsites of their target genes and the individual dimers have distinct affinity and specificity for differentkappa-B sites. Different dimer combinations act as transcriptional activators or repressors,respectively. NF-kappa-B complexes are held in the cytoplasm in an inactive state by members of theNF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B isphosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequentlydegraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The NFkappa-B heterodimer RELA/p65-c-Rel is a transcriptional activator.

Research Area

Cancer Biology

Images & Validation

• Tested Applications: WB
• Dilution Range: WB:1:1000-1:5000
• Reactivity: Human, Mouse

Key Properties

• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: C-terminal region of human REL
• Molecular Weight: 69
• Purity: Affinity purification
• Conjugation: Unconjugated

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Buffer/Preservatives: 0.01% NaN3
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

anti-REL antibody,anti-Protooncogene cRel antibody

Quick Database Links

UniProt

Q04864