PROTAC EGFR degrader 7

SKU: orb1982777

Description

PROTAC EGFR degrader 7 is a potent and selective CRBN-based degrader of EGFR L858R/T790M mutants, demonstrating a DC50 of 13.2 nM. It inhibits proliferation (IC50=46.82 nM), induces apoptosis and G2/M arrest in NCI-H1975 cells, showing promise for targeted NSCLC research both in vitro and in vivo.

Research Area

Cardiovascular Research, Cell Biology, Pharmacology & Drug Discovery, Signal Transduction

Images & Validation

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Key Properties

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MW	836.94
Formula	C₄₆H₄₈N₁₀O₆
Target	Apoptosis,Others,PROTACs,EGFR

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Gene Symbol

Apoptosis,Others,PROTACs,EGFR

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