PROTAC EGFR degrader 2

SKU: orb1983028

Description

PROTAC EGFR degrader 2 is a highly potent bifunctional molecule with an antiproliferative IC50 of 4.0 nM and induces EGFR degradation with a DC50 of 36.51 nM. Its adaptable linker makes it a valuable chemical tool for constructing NTR-responsive PROTACs, enabling targeted protein degradation research in both cellular and animal models of cancer.

Research Area

Cardiovascular Research, Cell Biology, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 3031336-58-7
• MW: 1151.78
• Formula: C₅₈H₇₂ClFN₁₂O₈S
• SMILES: N(C=1C2=C(C=C(OCCCCCC3=CN(CCOCCOCC(N[C@H](C(=O)N4[C@H](C(NCC5=CC=C(C=C5)C=6SC=NC6C)=O)C[C@@H](O)C4)C(C)(C)C)=O)N=N3)C(NC(/C=C/CN7CCCCC7)=O)=C2)N=CN1)C8=CC(Cl)=C(F)C=C8
• Target: EGFR,PROTACs

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

EGFR,PROTACs