Lys-PEG3-BA

SKU: orb3177191

Description

Lys-PEG3-BA is a PROTAC degrader targeting EML4-ALK/EGFR, with DC50 values of 1.32 μM for H3122 cells (expressing EML4-ALK fusion protein) and 19.66 μM for H1975 cells (with EGFRL858R/T790M mutations). In vitro studies show that Lys-PEG3-BA can inhibit the proliferation of non-small cell lung cancer cells by modulating the ubiquitin-proteasome system. Lys-PEG3-BA is applicable for research related to non-small cell lung cancer.

Key Properties

• CAS Number: 3057939-67-7
• MW: 818.35
• Formula: C₃₈H₅₇ClN₉O₇P
• SMILES: O(C)C=1C=C(C=CC1NC=2N=C(NC3=C(P(C)(C)=O)C=CC=C3)C(Cl)=CN2)N4CCN(C(CCOCCOCCOCCNC([C@H](CCCCN)N)=O)=O)CC4
• Target: EGFR,ALK,PROTACs

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

EGFR,ALK,PROTACs