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PROTAC EGFR degrader 7 diTFA

SKU: orb1943385

Description

PROTAC EGFR degrader 7 is a potent and selective CRBN-based degrader of the EGFRL858R/T790M mutant (DC50 = 13.2 nM). It demonstrates robust anti-proliferative activity (IC50 = 46.82 nM in NCI-H1975 cells), induces apoptosis and G2/M arrest, supporting its application in targeted protein degradation and NSCLC research.

Research Area

Cell Biology, Pharmacology & Drug Discovery

Images & Validation

Key Properties

TargetPROTACs

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information