Presenilin 1 (PS-1) Antibody

SKU: orb3167653

Description

Our Anti-Presenilin 1 (PS-1) rabbit polyclonal primary antibody detects human and mouse Presenilin 1 (PS-1), and is IgG. It is validated for use in WB.

Images & Validation

• Tested Applications: IF, WB
• Dilution Range: WB: 1:2000; IHC: 1:100; ICC: 1:100
• Reactivity: Human, Mouse
• Application Notes:
  On SDS-PAGE, the predominant form detected by this antibody is the N-terminal Presenilin 1 fragment of approx 29 kDa. The uncleaved form of Presenilin 1 migrates to approx 45 kDa. Human and mouse brain samples commonly prepared with reducing agent (50 mM DTT), urea (2.3M), SDS (1%) in 62.5 mM Tris-HCl pH 6.8 sample buffer heated to 50 C for 15 min. The suggested dilution for IF is 1:100 for acetone or paraformaldehyde fixed cells or tissue.

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Key Properties

• Host: Rabbit
• Clonality: Polyclonal
• Isotype: IgG
• Immunogen: A synthetic peptide corresponding to a region (1-20 aa) from the N-terminus of human Presenilin 1 conjugated to Diptheria toxoid.
• Target: Presenilin 1 (PS-1)
• Molecular Weight: 29 kDa, 45 kDa (see application details)
• Conjugation: Unconjugated

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Form/Appearance: Lyophilized
• Buffer/Preservatives: Lyophilized from PBS, pH 7.4. Contains no preservative.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Presenilin 1; PS-1; Protein S182; PS1-CTF12; PSEN1; AD3; PS1; PSNL1;

Quick Database Links

Gene Symbol

Presenilin 1 (PS-1)

UniProt

P49768