Pan Cytokeratin Antibody Cocktail (Acidic + Basic)

Catalog Number: orb749935

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Catalog Number	orb749935
Category	Antibodies
Description	Twenty human keratins are resolved with two-dimensional gel electrophoresis into acidic (pI 6.0) subfamilies. This antibody cocktail recognizes acidic (Type I or LMW) and basic (Type II or HMW) cytokeratins, which include Keratins 1, 3, 4, 5, 6, 8, 10, 14, 15, 16, and 19. Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis. KRTL/KRTH is a broad spectrum anti pan-cytokeratin antibody cocktail, which differentiates epithelial tumors from non-epithelial tumors e.g. squamous vs. adenocarcinoma of the lung, liver carcinoma, breast cancer, and esophageal cancer. It has been used to characterize the source of various neoplasms and to study the distribution of cytokeratin containing cells in epithelia during normal development and during the development of epithelial neoplasms. This antibody stains cytokeratins present in normal and abnormal human tissues and has shown high sensitivity in the recognition of epithelial cells and carcinomas.
Clonality	Monoclonal
Species/Host	Mouse
Isotype	Mouse IgG1, kappa
Conjugation	Unconjugated
Reactivity	Human, Rat
Immunogen	Recombinant human KRT77 and KRT76 protein were used as the immunogen for the pan Cytokeratin antibody.
UniProt ID	pan
Tested applications	IHC-P
Dilution range	Immunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT
Application notes	Optimal dilution of the GITR antibody should be determined by the researcher.
Antibody Type	Primary Antibody
Clone Number	KRTL/1077 + KRTH/1076
Formula	0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Note	For research use only