PAI-1 Antibody

SKU: orb3169653

Description

Anti-SERPINE1 Antibody is a humanized monoclonal antibody targeting Serpin Family E Member 1 (SERPINE1/PAI-1). SERPINE1, also known as Plasminogen Activator Inhibitor-1 (PAI-1), is the primary physiological inhibitor of tissue-type (tPA) and urokinase-type (uPA) plasminogen activators, playing a critical role in regulating fibrinolysis, cell migration, and tissue remodeling. Elevated PAI-1 levels are associated with thrombosis, fibrosis, metabolic syndrome, and tumor progression (including immune evasion and metastasis). Anti-SERPINE1 Antibody specifically binds to PAI-1, neutralizing its inhibitory activity and restoring tPA/uPA-mediated plasmin generation to promote fibrinolysis and reduce extracellular matrix deposition. Additionally, the antibody blocks PAI-1-mediated upregulation of PD-L1, thereby enhancing anti-tumor immune responses in the tumor microenvironment, and possesses potential anti-senescence properties.

Key Properties

• Antibody Type: Inhibitor Antibody
• Clonality: Monoclonal
• Target: PAI-1
• Conjugation: Unconjugated

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

PAI-1