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MS432

SKU: orb1989674

Description

MS432 is a PROTAC degrader that selectively targets MEK1 and MEK2 for ubiquitination and degradation via the VHL E3 ligase. This compound, derived from PD0325901, is a valuable chemical tool for investigating MEK/ERK pathway biology in both cellular and in vivo models of cancer and other diseases.

Research Area

Pharmacology & Drug Discovery, Signal Transduction

Images & Validation

Key Properties

MW1076.06
FormulaC50H65F3IN7O6S
SMILESO=C(N[C@@H](C)C1=CC=C(C=C1)C2=C(N=CS2)C)[C@H]3C[C@@H](O)CN3C([C@@H](NC(CCCCCCCCCCNCCCONC(C4=CC=C(C(F)=C4NC5=CC=C(C=C5F)I)F)=O)=O)C(C)(C)C)=O
TargetPROTACs,MEK

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

MS432 (orb1989674)

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(Recommended: An additional animal making an allowance for loss during the experiment)

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