Boc-11-aminoundecanoic acid

SKU: orb1307507

Description

Boc-11-aminoundecanoic acid is an alkyl/ether-based linker used in constructing PROTAC degraders like MS432. This bifunctional molecule connects an E3 ligase ligand to a target protein binder, enabling the study of targeted protein degradation in biochemical and cellular research.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 10436-25-6
• MW: 301.42
• Purity: 99.64%
• Formula: C₁₆H₃₁NO₄
• SMILES: O(C(NCCCCCCCCCCC(O)=O)=O)C(C)(C)C
• Target: PROTAC Linker

Bioactivity

• In Vitro:
  MS432 represents a pioneering and highly selective VHL-recruiting PROTAC degrader, specifically designed based on PD0325901, targeting MEK1 and MEK2. PROTACs are bifunctional molecules, comprising two ligands joined by a linker; one ligand interacts with an E3 ubiquitin ligase, while the other targets the protein of interest. By leveraging the cell's ubiquitin-proteasome system, PROTACs achieve selective degradation of their target proteins.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Boc 11 aminoundecanoic acid, Boc11aminoundecanoic acid, Boc-11-aminoundecanoic acid, cancer, Alkyl/ether, inhibit, MS432, linker, Inhibitor, protac, PROTACLinker, PROTAC Linkers, PROTAC Linker

Compound Identifiers

PubChem CID

4229290