Lidocaine hydrochloride

SKU: orb1224105

Description

Lidocaine HCl salt, an amide local anesthetic, has anti-inflammatory properties in vitro and in vivo, possibly due to an attenuation of pro-inflammatory cytokines, intracellular adhesion molecule-1 (ICAM-1), and reduction of neutrophils influx.

Research Area

Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	73-78-9
MW	270.8
Purity	>98% (HPLC)
Formula	C₁₄H₂₂N₂O·HCl
SMILES	Cl.CCN(CC)CC(=O)NC1=C(C)C=CC=C1C
Target	Sodium Channel
Solubility	Soluble in DMSO

Bioactivity

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In Vitro

Cell Proliferation Assay Cell line: The human gastric cancer cell line MKN45. Concentration: 10 nM. Incubation time: 48 hours. Result: Decreased significantly cell proliferation. Cell Viability Assay Cell line: The human gastric cancer cell line MKN45. Concentration: 1, 5 and 10 nM. Incubation time: 24, 48, 72 hours. Result: Inhibited MKN45 cell viability. Apoptosis Analysis Cell line: The human gastric cancer cell line MKN45. Concentration: 10 nM. Incubation time: 48 hours. Result: Increased significantly the apoptotic cell rate. Western blot analysis. Cell line: The human gastric cancer cell line MKN45. Concentration: 10 nM. Incubation time: 48 hours. Result: Down-regulated Cyclin D1 and up-regulated p21 expression significantly.

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Quality Guarantee

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Quick Database Links

Gene Symbol

Sodium Channel

Protocol Information

Find More Protocols

Purity:	97.37% (May vary between batches)
CAS Number:	5369-00-6
MW:	256.77
Formula:	C₁₃H₂₁ClN₂O

Purity:	99.95% (May vary between batches)
CAS Number:	6108-05-0
MW:	288.82
Formula:	C₁₄H₂₂N₂O·HCl·H₂O

Purity:	>99.99% (May vary between batches)
CAS Number:	73-78-9
MW:	270.798
Formula:	C₁₄H₂₃ClN₂O

Purity:	99.94% (May vary between batches)
CAS Number:	5875-06-9
MW:	330.86
Formula:	C₁₆H₂₆N₂O₃·HCl

Purity:	>98% (HPLC)
CAS Number:	6108-05-0
MW:	288.82
Formula:	C₁₄H₂₂N₂O·HCl·H₂O