Lidocaine hydrochloride

SKU: orb1224105

Description

Lidocaine HCl salt, an amide local anesthetic, has anti-inflammatory properties in vitro and in vivo, possibly due to an attenuation of pro-inflammatory cytokines, intracellular adhesion molecule-1 (ICAM-1), and reduction of neutrophils influx.

Key Properties

• CAS Number: 73-78-9
• MW: 270.8
• Purity: >98% (HPLC)
• Formula: C₁₄H₂₂N₂O·HCl
• SMILES: Cl.CCN(CC)CC(=O)NC1=C(C)C=CC=C1C
• Target: Sodium Channel
• Solubility: Soluble in DMSO

Bioactivity

• In Vitro:
  Cell Proliferation Assay Cell line: The human gastric cancer cell line MKN45. Concentration: 10 nM. Incubation time: 48 hours. Result: Decreased significantly cell proliferation. Cell Viability Assay Cell line: The human gastric cancer cell line MKN45. Concentration: 1, 5 and 10 nM. Incubation time: 24, 48, 72 hours. Result: Inhibited MKN45 cell viability. Apoptosis Analysis Cell line: The human gastric cancer cell line MKN45. Concentration: 10 nM. Incubation time: 48 hours. Result: Increased significantly the apoptotic cell rate. Western blot analysis. Cell line: The human gastric cancer cell line MKN45. Concentration: 10 nM. Incubation time: 48 hours. Result: Down-regulated Cyclin D1 and up-regulated p21 expression significantly.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Sodium Channel