Proparacaine hydrochloride

SKU: orb1310819

Description

Proparacaine hydrochloride

Research Area

Cell Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 5875-06-9
• MW: 330.86
• Purity: 99.87%
• Formula: C₁₆H₂₆N₂O₃·HCl
• SMILES: Cl.CCCOc1ccc(cc1N)C(=O)OCCN(CC)CC
• Target: Sodium Channel,Apoptosis
• Solubility: DMSO:55 mg/mL (166.23 mM);H2O:61 mg/mL (184.37 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.04 mM)

Bioactivity

• Target IC50:
  Nav:3.4 mM(ED50)
• In Vivo:
  Proparacaine inhibits corneal epithelial migration and adhesion through alteration of the actin cytoskeleton. Proparacaine acts like bupivacaine or lidocaine and produces dose-related spinal blockades of motor function, proprioception and nociception. Intrathecal proxymetacaine also produces longer sensory blockade than motor blockade.
• In Vitro:
  Proparacaine is more potent and less toxic than cocaine. Proparacaine significantly increases in FHV-1 (P < 0.01), C. felis, and 28S rDNA Ct values when fusidic acid is used.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

eye, glucocorticomimetic, inhibit, immunomodulatory, Lidocaine, Inhibitor, Apoptosis, anesthetic, Voltage-gated sodium channel, Sodium Channel, SodiumChannel, Proxymetacaine, Proxymetacaine Hydrochloride, Proparacaine, Proparacaine HCl, Proparacaine hydrochloride, Proparacaine Hydrochloride, topical

Compound Identifiers

PubChem CID

517321