QX-222 chloride

SKU: orb1305695

Description

QX-222 chloride, the N-methyl derivative of lidocaine hydrochloride, is a sodium channel blocking agent. It is utilized in neuroscience and electrophysiology research to investigate sodium channel function and local anesthetic mechanisms in both in vitro and in vivo experimental models.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 5369-00-6
• MW: 256.77
• Purity: 96.21%
• Formula: C₁₃H₂₁ClN₂O
• SMILES: [Cl-].Cc1cccc(C)c1NC(=O)C[N+](C)(C)C
• Target: Sodium Channel
• Solubility: H2O:100 mM;DMSO:100 mg/mL (389.45 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (15.58 mM)

Bioactivity

• In Vivo:
  Intravenous infusion administration of 10 mg/kg QX-222 chloride for 7 days reverses spinal nerve ligation (SNL)-induced thermal hypersensitivity and induced antinociception in sham-operated rats.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Lidocaine N-Methyl Hydrochloride, Na channels, Na+ channel, Na+ channels, QX 222, QX 222 hloride, QX222, QX-222, QX-222 Chloride, SodiumChannel, Sodium Channel, trimethyl analogue, μ1-Y401C

Compound Identifiers

PubChem CID

9795082