KI-7

SKU: orb1298255

Description

KI-7 is a small molecule that acts as a positive allosteric modulator of the adenosine A2B receptor. It is used in research to study receptor signaling and has been applied in both in vitro and in vivo models investigating inflammation, hypoxia, and cancer biology.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1489263-00-4
• MW: 354.4
• Purity: 98.33% (May vary between batches)
• Formula: C₂₃H₁₈N₂O₂
• SMILES: O=C(Nc1ccccc1)C(=O)c1cn(Cc2ccccc2)c2ccccc12
• Target: Adenosine Receptor
• Solubility: DMSO:240 mg/mL (677.2 mM);10% DMSO+90% Corn Oil:3.3 mg/mL (9.31 mM)

Bioactivity

• In Vitro:
  KI-7 potentiates the cAMP accumulation induced by the non-selective A2B adenosine receptor agonist NECA (EC50=445.8 nM). KI-7 also potentiates the cAMP accumulation induced by the selective A2B adenosine receptor agonist BAY 60-6583 as well as by adenosine with EC50s of 2390 nM and 2550 nM, respectively.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

A2B, accumulation, allosteric, AdenosineReceptor, Adenosine Receptor, cAMP, inhibit, KI7, KI-7, KI 7, MSC, Inhibitor, Runx2, potentiate, Osterix, orthosteric, P1 receptor

Compound Identifiers

PubChem CID

73350966