DPA-714

SKU: orb1217424

Description

DPA-714 is a high affinity translocator protein (TSPO) ligand (Ki=7 nM). It is designed with a fluorine atom in its structure, allowing labelling with fluorine -18 and in vivo imaging using positron emission tomography. [18F]DPA-714 successfully assesses for the specific imaging of inflammation in various models of neuroinflammation and in a brain tumor model.

Key Properties

• CAS Number: 958233-07-3
• MW: 398.47
• Purity: >98% (HPLC)
• Formula: C₂₂H₂₇FN₄O₂
• SMILES: CCN(CC)C(Cc1c2nc(C)cc(C)n2nc1-c(cc1)ccc1OCCF)=O
• Target: TSPO
• Solubility: DMSO:41.67 mg/mL (104.57 mM; Need ultrasonic)

Bioactivity

• In Vivo:
  [18F]DPA-714 binding significantly increases In vivo as a result of AD‐like pathology and age in APPswe×PS1Δe9 mice.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

TSPO