N-Methylcytisine

SKU: orb1301312

Description

N-Methylcytisine (Caulophylline) exhibits high affinity (KD = 5 nM) for nicotinic acetylcholine receptors (nAChRs) from squid optical ganglia. Unlike its derivatives, cytisine effectively inhibits 14C-tubocurarine binding (Ki=7 nM). This compound is a valuable research tool for studying nAChR pharmacology and ligand interactions in neurobiological in vitro assays.

Research Area

Neuroscience

Key Properties

• CAS Number: 486-86-2
• MW: 204.27
• Purity: 99.89%
• Formula: C₁₂H₁₆N₂O
• SMILES: CN1C[C@@H]2C[C@H](C1)c1cccc(=O)n1C2
• Target: AChR
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (9.79 mM);DMSO:27.5 mg/mL (134.63 mM);Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.:Soluble

Bioactivity

• Target IC50:
  14C-tubocurarine:7 nM(Ki)

Storage & Handling

• Storage: keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, N Methylcytisine, inhibit, nAChR, Nicotinic acetylcholine receptors, NMethylcytisine, N-Methylcytisine, Caulophylline

Compound Identifiers

PubChem CID

670971