Dolastatin 10

SKU: orb1296722

Description

Dolastatin 10 is a potent antimitotic peptide that acts by inhibiting tubulin polymerization. Its mechanism has been extensively studied in vitro and it has served as a lead compound for the development of novel anticancer agents evaluated in preclinical in vivo models.

Research Area

Signal Transduction

Key Properties

• CAS Number: 110417-88-4
• MW: 785.09
• Purity: 99.55% (May vary between batches)
• Formula: C₄₂H₆₈N₆O₆S
• SMILES: CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)c1nccs1)OC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C)C(C)C
• Target: ADC Cytotoxin,Microtubule Associated
• Solubility: DMSO:100 mg/mL (127.37 mM)

Bioactivity

• In Vitro:
  Dolastatin 10, a unique pentapeptide isolated from the sea hare Dolabella auricularia, has GI50 values of 10⁻⁵-10⁻⁶ μg/mL (10⁻²-10⁻³ nM) against a similar minipanel of human cell lines, comparable to Auristatin PE. The antibody-drug conjugate (ADC) consists of the anti-CD30 monoclonal antibody cAC10 conjugated to monomethyl auristatin E (MMAE), a synthetic analog of the tubulin polymerization inhibitor Dolastatin 10.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DLS 10, DLS10, DLS-10, Dolastatin 10, Dolastatin10, Dolastatin-10, ADCCytotoxin, ADC Cytotoxin, ADC Payload, inhibit, NSC 376128, Microtubule/Tubulin, MicrotubuleAssociated, Microtubule Associated, NSC376128, NSC-376128, Inhibitor

Compound Identifiers

PubChem CID

9810929