MMAD

SKU: orb1302662

Description

MMAD (Demethyldolastatin 10) is a potent tubulin-binding agent used as a cytotoxic payload in antibody-drug conjugates (ADCs). Its mechanism of inhibiting microtubule assembly is applied in oncology research for evaluating ADC efficacy in both in vitro cytotoxicity assays and in vivo xenograft models.

Research Area

Signal Transduction

Key Properties

• CAS Number: 203849-91-6
• MW: 771.06
• Purity: 99.91% (May vary between batches)
• Formula: C₄₁H₆₆N₆O₆S
• SMILES: [H][C@]1(CCCN1C(=O)C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C(=O)[C@@H](NC(=O)[C@@H](NC)C(C)C)C(C)C)[C@H](OC)[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)c1nccs1
• Target: Microtubule Associated,ADC Cytotoxin
• Solubility: DMSO:24.5 mg/mL (31.77 mM)

Bioactivity

• In Vivo:
  The resulting antibody-drug conjugates (ADCs) demonstrated complete tumor regression in rodents and showed an improved toxicology profile in rats.
• In Vitro:
  MMAD (Monomethyl Dolastatin 10) undergoes a stable oxime-ligation to produce several nearly homogenous antibody-drug conjugates (ADCs) with a drug-to-antibody ratio of approximately 2.0. These conjugates exhibit favorable pharmacokinetic properties and potent in vitro cytotoxicity against HER2+ cancer cells. Furthermore, ADCs synthesized using site-specific unnatural amino acids display enhanced in vitro cytotoxicity compared to those prepared through cysteine alkylation after native interchain disulfide reduction.

Storage & Handling

• Storage: Powder: -20°C for 3 years | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, Monomethyl Dolastatin 10, Monomethyl Dolastatin10, Monomethyl Dolastatin-10, Monomethylauristatin D, Microtubule Associated, MicrotubuleAssociated, Microtubule/Tubulin, MMAD, inhibit, ADCCytotoxin, ADC Cytotoxin, ADC Payload, Demethyldolastatin 10, Demethyldolastatin10, Demethyldolastatin-10

Compound Identifiers

PubChem CID

10723894