CGRP: A Biomarker for Migraine

 

Migraine is a widespread and debilitating condition that impacts the lives of hundreds of millions of people globally. Since the 1990s, there has been significant progress in understanding migraines, leading to the development of new treatments aimed at reducing the personal and economic burden on patients. These treatments target the calcitonin gene-related peptide (CGRP) and include monoclonal antibodies against CGRP ligands or receptors, as well as small molecule antagonists for CGRP receptors. Despite these advancements, some patients do not respond to these treatments, emphasizing the need for biomarkers in managing migraines effectively.

Calcitonin Gene-Related Peptide (CGRP)

CGRP is a neuropeptide that plays a significant role in the nervous system and is involved in various physiological processes. Here’s an overview of CGRP:

Structure

• CGRP is a 37-amino acid peptide
• It is produced in both the central and peripheral nervous systems
• CGRP exists in two forms: alpha-CGRP and beta-CGRP, which are encoded by different genes but have similar functions

Physiological Roles

• Vasodilation: CGRP is a potent vasodilator, meaning it can widen blood vessels. This is important in regulating blood flow and blood pressure
• Pain Transmission: It is involved in the transmission of pain signals, particularly in the context of migraine headaches
• Neurotransmission: CGRP acts as a neurotransmitter and neuromodulator, influencing various neuronal functions

CGRP and Migraines

During a migraine, calcitonin gene-related peptide (CGRP) levels rise in the blood and cerebrospinal fluid. This neuropeptide contributes to the migraine by causing the dilation of blood vessels (vasodilation) and activating the trigeminal nerve, which is responsible for transmitting pain signals. The combined effect of these actions leads to the characteristic pain and other symptoms associated with migraines.

To aid your research, Biorbyt offers ELISA kits, recombinant proteins, antibodies, and small molecule products for measuring CGRP in various species. Below are some of our best-selling items:

CGRP ELISA Kits

Name	Catalog Number
Human CGRP ELISA Kit	orb438605
Human CGRP1(CalcitoninGene Related Peptide 1) ELISA Kit	orb775074
Mouse CGRP1(CalcitoninGene Related Peptide 1) ELISA Kit	orb776257
Mouse CGRP2(Calcitonin Gene Related Peptide 2) ELISA Kit	orb774903
Rat CGRP1(CalcitoninGene Related Peptide 1) ELISA Kit	orb776256
Rat CGRP2(Calcitonin Gene Related Peptide 2) ELISA Kit	orb775295
Chicken CGRP1(CalcitoninGene Related Peptide 1) ELISA Kit	orb1146908
Dog CGRP1(CalcitoninGene Related Peptide 1) ELISA Kit	orb779840
Pig CGRP2(Calcitonin Gene Related Peptide 2) ELISA Kit	orb1291353

CGRP Recombinant Proteins

Name	Catalog Number
Recombinant Human Calcitonin gene-related peptide 1 (CALCA), Partial	orb245620
Recombinant Human Calcitonin gene-related peptide 2 (CALCB)	orb54331
Recombinant Dog Calcitonin (CALCA)	orb358731

CGRP Antibodies

Name	Catalog Number
CALCA（Calcitonin gene-related peptide 1/Alpha-type CGRP） antibody	orb10379
CGRP（Calcitonin gene-related peptide 1/Alpha-type CGRP） antibody	orb182870
CGRP（Calcitonin gene-related peptide 2/Beta-CGRP） antibody	orb357919
CGRP（Calcitonin gene-related peptide 2/Beta-CGRP） antibody	orb647197

CGRP Small Molecules

Name	Catalog Number
CGRP antagonist 1	orb1708126
Human CGRP	orb321008
α-CGRP (human) acetate	orb1296388

If you have any questions or wish to discuss any of these products further, please feel free to reach out to our Technical Support team at . We are here to assist you and look forward to helping you with your inquiries.